CD3 anticorps

N° du produit ABIN1177372

Cet anticorps Souris Monoclonal détecte spécifiquement CD3 dans FACS et Func. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour CD3 anticorps (ABIN1177372)

Antigène: CD3

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: UCHT1

Détail du produit anti-CD3 anticorps

Marque: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-CD3 (ABIN1177372)

Beverley, Callard: "Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody." dans: European journal of immunology, Vol. 11, Issue 4, pp. 329-34, (1981) (PubMed).

Détails sur CD3

Antigène: CD3

Autre désignation: CD3

Sujet: The UCHT1 monoclonal antibody specifically binds to the human CD3epsilon-chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex. CD3epsilon is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the HLDA Workshop show that this antibody is mitogenic for CD3epsilon-positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody. CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3epsilon unlike the other CD3 clone, HIT3a, that stains only extracellular CD3epsilon.
Synonyms: CD3e, CD3E, T3E, TCRE , T-cell surface antigen T3/Leu-4 epsilon

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway